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Precautions and Warnings With Paliperidone Palmitate

People who are receiving injections of paliperidone palmitate should be aware of the drug's warnings and precautions -- in particular, that this medication may increase your risk for strokes, heart rhythm problems, or other potentially dangerous complications. To help ensure a safe treatment with this antipsychotic medicine, make sure your healthcare provider is aware of your medical history and current medications.

What Should I Tell My Healthcare Provider Before Receiving Paliperidone Palmitate?

You should talk with your healthcare provider prior to receiving paliperidone palmitate (Invega® Sustenna®) if you have:
 
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Kidney disease, such as kidney failure
  • Any kind of dementia, including Alzheimer's dementia or dementia with Lewy bodies (DLB)
  • Parkinson's disease
  • A certain heart arrhythmia known as QT prolongation or long QT syndrome
  • Any other heart arrhythmia (abnormal heartbeat)
  • Low blood pressure (hypotension)
  • Diabetes or high blood glucose (sugar) or a close family member with diabetes
  • High cholesterol
  • Heart disease or congestive heart failure
  • A history of a heart attack or stroke
  • Been told you have a low white blood cell count
  • Have low levels of potassium or magnesium in your blood
  • Seizures or a seizure disorder
  • Ever had thoughts of suicide or harming yourself
  • A tendency to be dehydrated or will be exposed to high temperatures
  • A history of dizziness or fainting
  • Narrowing or blockage of the stomach or intestines
  • Difficulty swallowing
  • Any allergies, including to foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
 
  • Breastfeeding
  • Pregnant or thinking of becoming pregnant.
 
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 
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