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Paliperidone Palmitate

How Does It Work?

Paliperidone palmitate belongs to a group of medicines known as atypical antipsychotics (also called second-generation antipsychotics). It is thought to work by blocking the action of dopamine, a neurotransmitter (chemical) in the brain that is believed to be elevated in people with schizophrenia. Like other atypical antipsychotics, paliperidone palmitate also blocks a type of serotonin (another chemical found in the brain) receptor, which is believed to help control some of the symptoms of schizophrenia.
Paliperidone palmitate is given as an injection into a muscle. After each dose, the medication is removed from the body slowly, allowing for once-a-month dosing.

When and How to Receive This Medicine

Some general considerations to keep in mind during treatment with paliperidone palmitate include the following:
  • This medication comes as a liquid that is given as an injection into a muscle (an intramuscular, or IM, injection) once a month.
  • The injection is administered by a healthcare provider in an office or clinic.
  • The first two paliperidone palmitate injections are given into the shoulder (deltoid muscle). Subsequent injections can be given in the buttocks (gluteal muscle) or shoulder.
  • For this drug to work properly, it must be used as prescribed. Your symptoms may return if you stop using this medication or miss a dose.

Storage Information

Paliperidone palmitate will be stored by your healthcare provider. It should be stored at room temperature. Make sure to keep this and all other medications out of the reach of children.

Is There a Generic Version?

This medication is not available in generic form (see Generic Invega Sustenna).
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Paliperidone Palmitate Drug Information

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