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Paliperidone Palmitate Dosage

Your healthcare provider will take several factors into consideration when determining an appropriate dosage of paliperidone palmitate. Some of these factors include how you respond to the drug, other medical conditions you have, and other medications you are taking. The medicine comes as an injection that is administered by your healthcare provider once a month.

An Introduction to Your Dosage of Paliperidone Palmitate

The dose of paliperidone palmitate (Invega® Sustenna®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • How you respond to the medication
  • Other medical conditions you may have
  • Other medications you are taking.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Paliperidone Palmitate Dosing Guidelines

The standard initial dosage of paliperidone palmitate for the treatment of schizophrenia is a first-time dose of 234 mg. A dosage of 156 mg is given one week later, followed by a once-a-month maintenance dosage of 117 mg given every four weeks.
Some people may be switched from paliperidone tablets (available as Invega®) to paliperidone palmitate. The recommended maintenance dose to replace paliperidone tablets is as follows:
  • Paliperidone palmitate 234 mg every four weeks for people taking paliperidone 12 mg a day
  • Paliperidone palmitate 117 mg every four weeks for people taking paliperidone 6 mg a day
  • Paliperidone palmitate 39 to 78 mg every four weeks for people taking paliperidone 3 mg a day.
Some people may need lower or higher doses, depending on how well the medication is tolerated and how well it works to control symptoms. The manufacturer recommends that maintenance doses be no lower than 39 mg and no higher than 234 mg.
People who are switching from another long-acting injectable antipsychotic to paliperidone palmitate do not need to receive the first two doses that are given one week apart. Instead, they can begin their maintenance dose on the day of their regularly scheduled antipsychotic injection.
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