Drug Interactions With Paliperidone Palmitate
More Detail on Drug Interactions With Paliperidone PalmitateThe following sections explain in detail the potentially negative reactions that can occur when paliperidone palmitate is combined with any of the drugs listed above.
Drinking alcohol may increase your risk for certain paliperidone palmitate side effects, such as drowsiness, dizziness, or lightheadedness. This could make it unsafe to perform tasks that require mental alertness, such as driving, even if you believe you feel fine.
Carbamazepine may decrease blood levels of paliperidone palmitate. Your healthcare provider may choose to give you a higher paliperidone palmitate dose if you use it with carbamazepine. In addition, your paliperidone palmitate dosage may need to be adjusted each time your carbamazepine dosage is changed.
Paliperidone palmitate may cause a certain change in the heart rhythm known as QT prolongation. Combining this medication with other medicines that can cause QT prolongation increases your risk for this life-threatening arrhythmia. Your healthcare provider may choose to monitor the electrical activity of your heart, using an electrocardiogram (ECG), if you use paliperidone palmitate with another QT-prolonging medication.
Medications That Cause Drowsiness
Combining paliperidone palmitate with other medications that cause drowsiness may increase your risk for side effects, such as drowsiness, dizziness, or lightheadedness. This could make it unsafe to perform tasks that require mental alertness, such as driving.
Combining paliperidone palmitate with metoclopramide could increase your risk for serious movement disorders known as extrapyramidal side effects. It could also increase your risk for neuroleptic malignant syndrome (NMS), a rare but life-threatening neurological disorder associated with antipsychotic use (see Paliperidone Palmitate Side Effects for a list of possible extrapyramidal and NMS symptoms). In general, paliperidone palmitate should not be combined with metoclopramide.