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Precautions and Warnings With Molindone

There are several precautions and warnings with molindone to be aware of before starting treatment. For example, it is important to know that the drug may cause neuroleptic malignant syndrome, tardive dyskinesia, seizures, and depression. Precautions and warnings with molindone also include people who are allergic to any components of the drug or who are in a coma or state of decreased consciousness.

As of January 2010, the manufacturer of molindone has decided to stop making this medication. It is predicted that all current supplies will be depleted by June 2010. All people taking molindone should talk with their healthcare providers immediately about switching to a different medication.

Molindone: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking molindone hydrochloride (Moban®) if you have:
Also, let your healthcare provider know if you:
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding
  • Drink alcohol.
You should also be sure to tell your healthcare provider about all medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Molindone

Warnings and precautions to be aware of prior to taking molindone include the following:
  • The medication can cause tardive dyskinesia. This is a condition involving unusual, uncontrollable body or facial movements. It can become permanent even if molindone is stopped. The best way to prevent this is to tell your healthcare provider right away if you notice any abnormal movements (including abnormal movements of the tongue) while taking molindone.
  • Molindone can cause a life-threatening condition called neuroleptic malignant syndrome (NMS). Some symptoms of NMS include:
    • A high fever
    • Stiff muscles
    • Confusion
    • Irregular pulse or blood pressure
    • A fast heart rate (tachycardia)
    • Sweating
    • Irregular heart rhythms (arrhythmias).
Tell your healthcare provider right away if think you might have NMS.
  • Molindone can impair your mental or physical abilities to drive a car or operate heavy machinery, especially when you first start taking it. Make sure you know how the drug affects you before you perform any activities that require mental concentration or physical coordination.
  • Molindone can increase the level of prolactin (a natural hormone) in your blood. This can cause various problems, such as breast enlargement, breast discharge, menstrual changes, or sexual problems.
  • The medication may cause depression or make it worse in people who already have it. Talk to your healthcare provider before taking molindone if you have a history of depression.
  • Molindone may increase the risk of seizures, although this risk is most likely quite low compared to other antipsychotic medications. Before starting treatment, tell your healthcare provider if you have epilepsy or a history of seizures.


  • Antipsychotics like molindone have been reported to cause low white blood cells. Let your healthcare provider know if you develop frequent or persistent infections, as this may be a sign of low white blood cells. If you already have a low white blood cell count (or have had such a problem in the past), your healthcare provider should monitor your white blood cell count frequently during the first few months you take molindone. 


  • Molindone is considered a pregnancy Category C medication. This means that it may not be safe to take while pregnant. Be sure to talk with your healthcare provider about the risks and benefits of using the drug during pregnancy (see Moban and Pregnancy).
  • It is not know if molindone passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider before using the drug (see Moban and Breastfeeding).
  • Molindone can interact with certain other medications (see Drug Interactions With Molindone).
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