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Drug Interactions With the Methylphenidate Patch

Methylphenidate Patch Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when methylphenidate patch is combined with any of the drugs listed above.
 
Blood Pressure Medication
Using the methylphenidate patch with high blood pressure medication can cause the blood pressure medication to be less effective, increasing your risk of high blood pressure (hypertension). Your healthcare provider may need to increase your dose of blood pressure medicine.
 
Monoamine Oxidase Inhibitors (MAOIs)
Using the methylphenidate patch and MAOIs together can cause life-threatening side effects, such as very high blood pressure. Do not use the methylphenidate patch and MAO inhibitors together unless your healthcare provider specifically tells you to do so. Do not use methylphenidate patches if you have taken an MAOI within the past two weeks.
 
Pressors
Taking a pressor while using the methylphenidate patch can cause an increase in side effects, particularly increased blood pressure and heart rate. Your healthcare provider may need to monitor your heart rate and blood pressure closely and adjust your dose of these drugs if necessary.
 
Seizure Medications
Using the methylphenidate patch with seizure medications can increase the amount of the seizure medication in your blood, perhaps increasing your risk of side effects. Your healthcare provider may need to decrease your dose of the seizure medication.
 
SSRI Antidepressants
Using the methylphenidate patch with a SSRI antidepressant can increase the amount of the antidepressant in your blood, perhaps increasing your risk of side effects. Your healthcare provider may need to decrease your dose of the depression medication.
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Methylphenidate Patch (Daytrana)

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