Drug Interactions With Methamphetamine (Cont.)

Methamphetamine Interactions Explained

 
Guanethidine
Taking methamphetamine and guanethidine together can decrease the effectiveness of the guanethidine. Your healthcare provider may need to adjust your dose of these drugs.
 
Insulin
Taking methamphetamine with insulin can increase your risk of low blood sugar (hypoglycemia). You may eat less while taking methamphetamine (because methamphetamine is an appetite suppressant), and your healthcare provider may need to decrease your insulin dose.
 
Monoamine Oxidase Inhibitors (MAOIs)
Taking methamphetamine and MOA inhibitors together can cause life-threatening side effects, such as very high blood pressure. Do not take methamphetamine if you have taken an MAOI within the past 14 days.
 
Phenothiazines
Taking methamphetamine and phenothiazines together may decrease the effectiveness of methamphetamine. Your healthcare provider may need to adjust your dose of these drugs.
 
Tricyclic Antidepressants
Taking methamphetamine and tricyclic antidepressants together can change the way the brain reacts to methamphetamine, possibly causing more side effects. Your healthcare provider may need to adjust your dose of these drugs.
 

Final Thoughts on Methamphetamine Drug Interactions

It is possible that not every methamphetamine drug interaction was discussed in this article. Therefore, you should talk with your healthcare provider about the specific drug interactions with methamphetamine that may apply to you.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;