Mental Health Channel
Topics & Medications
Quicklinks
Related Channels

Methadone Drug Interactions

Medications That Cause Drowsiness
Combining methadone with any other medications that cause drowsiness can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking these medications together.
 
In addition, some pain medications and addiction treatment medications may actually interfere with methadone, perhaps leading to methadone withdrawal symptoms. Check with your healthcare provider before combining these medicines.
 
Monoamine Oxidase Inhibitors (MAOIs)
Combining medications similar to methadone with an MAOI can cause life-threatening reactions, although similar problems have not been reported with methadone. Nonetheless, methadone should be started with caution in people who have taken an MAOI in the past 14 days.
 
Phenytoin
Phenytoin may increase the metabolism of methadone into normeperidine (the toxic metabolite). This may decrease the effectiveness of methadone, while increasing the risk of dangerous side effects. Check with your healthcare provider before taking these drugs together.
 
Some Protease Inhibitors
Although it was predicted that protease inhibitors would increase the level of methadone in the blood (which might increase the risk of side effects), research suggests that some protease inhibitors may actually have the opposite effect. In particular, nelfinavir (Viracept®), ritonavir (Norvir®), and lopinavir and ritonavir (Kaletra®) seem to decrease the level of methadone in the blood.
 
Check with your healthcare provider before combining methadone with any protease inhibitor.
 
Stavudine
Methadone may decrease the level of stavudine in the blood, potentially making it less effective. Check with your healthcare provider before taking these medications together. Your healthcare provider may need to increase your stavudine dosage.
5 Common Relationship Mistakes for Adults With ADHD

Methadone Medication Information

Terms of Use
Advertise with Us
Contact Us
About eMedTV
Privacy Policy
Copyright © 2006-2017 Clinaero, Inc.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.