Mellaril Drug Interactions

When medicines like paroxetine or propranolol are taken together with Mellaril, drug interactions can potentially occur. Some of these interactions may increase the risk of a life-threatening condition called QT prolongation. You should make sure to talk with your pharmacist or healthcare provider about any Mellaril drug interactions that may apply to you.

 

An Introduction to Mellaril Drug Interactions

Mellaril® (thioridazine) can potentially interact with a number of other medicines. The most dangerous Mellaril interactions increase the risk of a life-threatening irregular heart rhythm (arrhythmia) called QT prolongation. These interactions involve medications that increase the level of Mellaril in your blood (which increases the risk of QT prolongation) and medications which can cause QT prolongation. QT prolongation is a lengthening of the QT interval, a certain part of the heart rhythm. It can be extremely dangerous.
 
Medications That Increase Mellaril Levels
Several medications increase Mellaril levels, increasing the risk of Mellaril side effects (including QT prolongation). These medications include but are not limited to:
 

 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;