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Marplan and Suicide

The FDA has issued a warning concerning antidepressants, such as Marplan, and suicide in children and teenagers. In studies, there was a slightly increased risk of suicidal thoughts or behavior in children and teenagers who took antidepressants such as Marplan. From what is known about Marplan and suicide, people with bipolar disorder and those who have previously attempted suicide are among those most at risk for suicidal behavior with the drug.

An Overview of Marplan and Suicide

Marplan® (isocarboxazid) is a prescription medication used for the treatment of depression in adults. It is part of a group of medications called monoamine oxidase inhibitors (MAOIs). As with all antidepressants, there may be an increased risk of suicidal behavior when taking Marplan.
 

Marplan and Suicide: FDA Warning

The U.S. Food and Drug Administration (FDA) has issued a special warning about the risk of suicidal thoughts and behavior with antidepressant use in children and teenagers. The warning was issued due to concerns that antidepressants seemed to increase the risk of suicidal behavior in children and teenagers in clinical studies.
 
Although Marplan is not recommended for use in children and teenagers under 16 years of age, it may be used "off-label" for these age groups.
 

Does Marplan Cause Suicides?

In clinical studies, it did appear that there was a slightly increased risk of suicidal behavior in children and teenagers who took antidepressants. In one study, about 4 percent of children and teens taking an antidepressant had suicidal thoughts or behavior, compared to 2 percent in children and teens who were not taking an antidepressant. This study looked at all suicidal behavior, including suicides, attempted suicides, and thoughts about committing suicide. It is important to note that no one in the study actually committed suicide.
 
It is difficult to know for sure if antidepressants cause suicidal behavior. To make matters more confusing, depression itself can cause suicidal behavior. The bottom line: you should report any signs of suicidal behavior to your healthcare professional, regardless of whether you are taking an antidepressant.
 
Certain people seem to be at a higher risk for suicidal behavior while taking antidepressants. This includes people with bipolar disorder (or a family history of bipolar disorder) and people who have attempted suicide (or have a family history of suicide attempts).
 
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Marplan Drug Information

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