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Drug Interactions With Maprotiline

Monoamine Oxidase Inhibitors (MAOIs)
Taking maprotiline with MAOIs can increase your chance of developing dangerous side effects. Do not take maprotiline if you have taken an MAOI within the past two weeks.
 
Phenothiazines
Taking maprotiline with phenothiazine medications can increase the level of maprotiline in your blood, increasing your risk of side effects. Also, combining maprotiline with certain phenothiazines can increase your risk of seizures or a dangerous irregular heart rhythm called QT prolongation. Talk to your healthcare provider before taking these medications together.
 
Pressors
Taking maprotiline with pressor medications can increase your risk of side effects. Your healthcare provider may need to adjust your dose of these medications.
 
SSRI or SNRI Medications
Taking maprotiline with SSRIs or SNRIs could increase your chance of side effects. Check with your healthcare provider before taking such medications together.
  
Thyroid Medications
Taking maprotiline with thyroid medications can increase your risk of maprotiline side effects. Your healthcare provider may need to adjust your dose of these medications.
 
Tricyclic Antidepressants
Taking maprotiline with other tricyclic antidepressants can increase your risk of side effects. Your healthcare provider may need to adjust your dose of these medications.
 

Final Thoughts on Maprotiline Drug Interactions

It is possible that not every maprotiline drug interaction was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific drug interactions with maprotiline that may apply to your situation.
 
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Maprotiline (Ludiomil)

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