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If alcohol, arrhythmia medications, or other tricyclic antidepressants are taken with Vivactil, drug interactions may occur that could lead to an increased risk of side effects. To help minimize these risks, tell your healthcare provider about all other medicines you may be taking. Other drugs that can cause Vivactil drug interactions include anticholinergic medications, tramadol, cimetidine, and thyroid medications.

Vivactil Drug Interactions: An Overview

Vivactil® (protriptyline hydrochloride) can potentially interact with many medicines. Some of the medicines that may lead to Vivactil drug interactions include:
  • Alcohol
  • Anticholinergic medications, including



  • Arrhythmia medications, including:



  • Cimetidine (Tagamet®)
  • Cisapride (Propulsid®)
  • Monoamine oxidase inhibitors (MAOIs), including:



  • Phenothiazine medications, including:



  • Pressors, including:


    • Dopamine (Intropin®)
    • Dobutamine (Dobutrex®)
    • Epinephrine (Adrenalin®, EpiPen®)
    • Norepinephrine (Levophed®)




  • Thyroid medications, including:





Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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