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Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to taking vilazodone if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • A history of seizures
  • Bipolar disorder (sometimes called manic depression) or mania
  • A history of suicide attempts or suicidal thoughts
  • Frequent alcohol intake
  • Low blood sodium levels
  • A history of bleeding problems
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Vilazodone to learn more, including information on who should not take the drug.)

How Does Vilazodone Work?

The exact way that vilazodone works to treat depression is unknown. Vilazodone works on a specific brain chemical called serotonin. Serotonin is one of several chemicals used to send messages between nerves. When serotonin levels become unbalanced, it can cause a variety of conditions, including depression.
Vilazodone increases the activity of serotonin in the brain by blocking the reuptake of serotonin by nerves, allowing more to be available in the space between the nerves. It also acts as a partial agonist at certain serotonin receptors. This means it binds to the receptors, but only causes part of the response that would be expected from the binding of serotonin itself.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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