Mental Health Home > Side Effects of Vilazodone

Some common vilazodone side effects to watch for include nausea, diarrhea, dry mouth, and dizziness. In general, this drug is well tolerated, and most people are able to take it without any problems. However, notify your healthcare provider immediately if you develop serious reactions, such as confusion, headache, or extreme feelings of happiness or elation.

An Introduction to Side Effects of Vilazodone

Just like any medicine, vilazodone (Viibryd™) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in many cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible vilazodone side effects. Your healthcare provider can discuss a more complete list with you.)

Serious Vilazodone Side Effects

Some side effects with vilazodone are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Suicidal thoughts or behavior, including thoughts of hurting yourself (see Viibryd and Suicide)
  • Signs of low blood sodium (hyponatremia), such as:
    • Confusion
    • Problems concentrating or memory problems
    • Headache
    • Unsteadiness or falling
    • Fainting.
  • Symptoms of mania, which may include:
    • Extreme feelings of happiness or elation
    • Much more energy than usual
    • Extreme difficulty sleeping
    • Racing thoughts or ideas
    • Talking very quickly or more than usual
    • An exaggerated sense of self-worth
  • Signs of serotonin syndrome (a rare but dangerous problem associated with medications that affect serotonin), such as:
    • Confusion or other mental changes
    • A rapid heart rate
    • Nausea, vomiting, or diarrhea
    • Hallucinations
    • High or low blood pressure
    • Muscle stiffness
    • Fever, sweating, or shivering
    • Incoordination
    • Twitching muscles
    • Shakiness
    • Agitation
    • Seizures
    • Coma
  • Any unusual bleeding or bruising
  • Signs of a stomach bleed, such as:
    • Weakness
    • Shortness of breath
    • Stomach pains
    • Black, tarry stools
    • Bloody vomit or vomit that looks like coffee grounds
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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