Mental Health Home > What Is Trazodone ER Used For?

Trazodone ER (extended-release) tablets are prescribed for treating depression in adults. Although it is not exactly known how this antidepressant works, it is known that it helps balance certain brain chemicals. Off-label uses for trazodone ER include treating insomnia, anxiety, and alcoholism. Make sure to give this medication a chance to work, as it can take a few weeks to notice a difference.

An Overview of Uses for Trazodone ER

Trazodone ER (Oleptro™) is a prescription medication approved for the treatment of depression. It is a long-acting, once-daily version of trazodone.
Depression is more than just "feeling sad." Some of the common symptoms of depression include:
  • Feelings of hopelessness or worthlessness
  • Decreased interest in things that you used to enjoy
  • Suicidal thoughts or behaviors
  • Changes in sleep (sleeping too much or not enough)
  • Changes in appetite (and weight gain or weight loss)
  • Physical pain.
In clinical trials, trazodone ER has been proven to help adults with depression. However, keep in mind that antidepressants often take a few weeks (or even longer) to begin working. Sometimes, other people (such as friends, relatives, or coworkers) will notice an improvement in your depression symptoms before you do.
Often, improvements in your physical symptoms of depression (such as pain or changes in sleep) will be most noticeable at first, before you notice significant improvements in mood. It is important to give the medication a chance to work before becoming discouraged.
Counseling and therapy (see Psychotherapy for Depression) are often used along with antidepressant medication to treat depression. Ask your healthcare provider if counseling or therapy would be good options for you (see Depression Treatment).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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