Mental Health Home > Drug Interactions With Trazodone ER

Several medications can cause negative drug interactions with trazodone ER, including anticoagulant medications, nonsteroidal anti-inflammatory drugs, or monoamine oxidase inhibitors. Some of these interactions could increase your risk of serious side effects or other complications, such as a dangerous condition called serotonin syndrome.

An Overview of Trazodone ER Interactions

Trazodone ER (Oleptro™) can potentially interact with a number of other medications. Some of the medicines that may interact with this product include but are not limited to:
  • Medications that "thin" the blood (such as anticoagulant and antiplatelet drugs), such as:
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)


Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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