Mental Health Home > Tofranil PM

Tofranil PM is a medicine licensed for the treatment of depression in adults. Part of a class of drugs known as tricyclic antidepressants, it helps to improve depression symptoms by affecting certain chemicals in the brain (serotonin and norepinephrine). It comes in capsule form and is generally taken once or twice a day. Side effects may include dizziness, difficulty urinating, and drowsiness.

What Is Tofranil PM?

Tofranil PM® (imipramine pamoate) is a prescription medication used to treat depression (also known as major depression or clinical depression) in adults. It is part of a class of drugs known as tricyclic antidepressants. Tofranil PM is different from Tofranil®, a similar medication that is approved to treat bedwetting in children in addition to depression in adults (see Imipramine for information about the differences between Tofranil and Tofranil PM).
(Click Tofranil PM Uses for more information, including possible off-label uses.)

Who Makes Tofranil PM?

Tofranil PM is made by Mallinckrodt Pharmaceuticals. Generic Tofranil PM is also made by Mallinckrodt Pharmaceuticals.

How Does Tofranil PM Work?

Tofranil PM belongs to a class of medications called tricyclic antidepressants. It is not entirely clear how this product works. However, it is known that the drug affects several chemicals in the brain, including serotonin and norepinephrine. It is thought that perhaps Tofranil PM allows these chemicals to stay in the brain longer, which can help with depression symptoms.
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Last reviewed by: Kristi Monson, PharmD;
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