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Serzone is a drug that is licensed to treat depression in adults. By balancing the levels of certain chemicals in the brain (serotonin and norepinephrine), the medicine can improve the symptoms of depression and reduce the chances of a relapse. Serzone comes in tablet form and is generally taken twice a day. Potential side effects can include headache, drowsiness, and nausea.

What Is Serzone?

Serzone® (nefazodone hydrochloride) is a prescription medicine used for the treatment of depression (also known as major depression or clinical depression).
(Click Serzone Uses for more information, including possible off-label uses.)

Who Makes It?

Serzone was originally manufactured by Bristol-Myers Squibb. However, Bristol-Myers Squibb voluntarily stopped making the medication, due to concerns of liver toxicity (see Serzone and Liver Failure). Generic versions are still available and are made by a few manufacturers.

How Does Serzone Work?

It is not entirely clear how Serzone works. No other medications work exactly like it. Serzone acts on specific chemicals within the brain known as serotonin and norepinephrine. These chemicals are used to send messages between nerves; when levels become unbalanced, however, it can cause a variety of conditions, including depression. Serzone helps to block the reuptake of serotonin and norepinephrine so that more is available for the nerves in the brain, returning the serotonin back to its "normal" levels. However, unlike selective serotonin reuptake inhibitors (SSRIs), Serzone may also block certain types of serotonin receptors.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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