Mental Health Home > Serzone Side Effects

Dry mouth, headache, and drowsiness are the most common side effects reported with Serzone. Side effects of the drug are generally minor and, in most cases, either don't require medical attention or can be treated easily. However, there are some potentially serious reactions that should be reported to a healthcare provider right away, including hallucinations, suicidal thoughts or behavior, and panic attacks.

Serzone Side Effects: An Introduction

As with any medicine, side effects are possible with Serzone® (nefazodone hydrochloride). However, not everyone who takes the antidepressant will experience problems. In fact, most people tolerate it well. If side effects do occur, in most cases, they are minor and either require no treatment or can be treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Serzone. Your healthcare provider can discuss a more complete list of side effects with you.)

Common Side Effects of Serzone

Serzone has been studied thoroughly in clinical trials, in which a group of people taking the drug have side effects documented and compared to another group not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
In these studies, the most common Serzone side effects included:
  • Headache -- in up to 36 percent of people
  • Dry mouth -- up to 25 percent (see Serzone and Dry Mouth)
  • Drowsiness -- up to 25 percent
  • Nausea -- up to 22 percent
  • Dizziness -- up to 17 percent
  • Constipation -- up to 14 percent
  • Weakness -- up to 11 percent
  • Insomnia -- up to 11 percent (see Serzone and Insomnia)
  • Lightheadedness -- up to 10 percent
  • Heartburn -- up to 9 percent
  • Blurred vision -- up to 9 percent
  • Infections -- up to 8 percent
  • Diarrhea -- up to 8 percent
  • Confusion -- up to 7 percent
  • Sore throat -- up to 6 percent.
Other common side effects (occurring in 1 to 5 percent of people) included:
  • Impotence (known as erectile dysfunction, or ED)
  • Increased appetite
  • Low blood pressure when standing or sitting up suddenly (orthostatic hypotension)
  • Memory problems or concentration problems
  • Unusual sensations, such as tingling or burning (paresthesias)
  • Flushing (redness of the skin, especially the face)
  • Flu-like symptoms, such as fever or chills
  • Fluid retention, especially in the legs
  • Abnormal dreams
  • Coughing
  • Problems with muscle coordination
  • Shakiness (tremor)
  • Ringing of the ears (tinnitus)
  • Taste changes
  • Frequent urination or difficulty urinating
  • Urinary tract infection (bladder infection)
  • Vaginal infection or irritation
  • Neck stiffness
  • Thirst
  • Joint pain
  • Muscle tension
  • Decreased sex drive
  • Breast pain.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
Other Articles in This eMedTV Presentation

Topics & Medications


Related Channels

eMedTV Links
Copyright © 2006-2021 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.