Mental Health Home > Serzone Sexual Side Effects

A number of side effects may occur with the use of Serzone. Sexual side effects that have been reported with the drug include impotence, decreased sex drive, and ejaculation problems. Since sexual symptoms are common in people with depression, however, it is difficult to determine whether these sexual problems are actually caused by the antidepressant itself. Let your healthcare provider know if you develop any Serzone sexual side effects so he or she can recommend treatment, adjust your dosage, or prescribe another depression medication.

Serzone Sexual Side Effects: An Overview

Serzone® (nefazodone hydrochloride), like many antidepressants, is known to cause certain sexual side effects. Serzone sexual side effects may include:
  • Decreased sex drive
  • Ejaculation problems
  • Impotence
  • Anorgasmia (inability to achieve orgasm)
  • Priapism (a painful erection that does not go away).
Sex Drive
Serzone is known to cause changes in sex drive (known as libido). In clinical studies where side effects of Serzone were documented, a decreased sex drive occurred in up to 1 percent of people.
Ejaculation Problems
Serzone is also known to cause abnormal ejaculation. This can include delayed ejaculation, retrograde ejaculation, or a complete inability to ejaculate. Retrograde ejaculation is "backward" ejaculation, when the ejaculate goes into the bladder instead of out through the penis. Retrograde ejaculation is generally painless and is usually not a problem. Symptoms of retrograde ejaculation include absence of ejaculate and cloudy urine.
In clinical studies where side effects of Serzone were documented, retrograde ejaculation occurred in between 1 in 100 to 1 in 1,000 men.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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