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Is SAM-e Effective?

Reliable evidence suggests that SAM-e may be effective for depression, arthritis, and intrahepatic cholestasis. However, not enough research has been done to know if it is effective for other uses.
(Click Does SAM-e Work? for more information.)

Dosing Information

Although less information is available on the dosing of supplements, such as SAM-e, compared to drugs, some information about dosing is available based on clinical studies and years of practical experience with the supplement.
(Click SAM-e Dosage for more information.)

Side Effects of SAM-e

Although it is a "natural" product, SAM-e can still cause side effects. Some of the more commonly reported side effects include:
(Click SAM-e Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)

Drug Interactions

SAM-e may interact with other supplements or medications (see SAM-e Drug Interactions).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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