Mental Health Home > SAM-e Drug Interactions
When certain medications are taken in combination with SAM-e, drug interactions may occur. These negative interactions can increase the risk of serotonin syndrome, which is a group of dangerous symptoms that consist of hallucinations, fever, muscle spasm, difficulty walking, and diarrhea. Medicines that may lead to SAM-e drug interactions include tramadol, St. John's wort, monoamine oxidase inhibitors, and meperidine.
- St. John's wort (Hypericum perforatum)
- Tramadol (Rybix™ ODT, Ryzolt®, Ultram®, Ultram® ER) or tramadol/acetaminophen (Ultracet®)
- Triptans (certain migraine medications), such as: