At this time, it is not clear if SAM-e and pregnancy is a safe combination. The supplement has been studied for treating intrahepatic cholestasis of pregnancy, but only in the third trimester and only in IV (not oral) form. However, this does not mean that SAM-e is safe for all pregnant women. If you are taking SAM-e and pregnancy occurs, notify your healthcare provider.
SAM-e and Pregnancy: An Overview
S-adenosyl-L-methionine (also known as SAM-e) is a non-prescription supplement used for a variety of different purposes, including intrahepatic cholestasis of pregnancy (ICP). Little information is available about the use of SAM-e during pregnancy. Although some studies suggest that intravenous (IV) SAM-e may be safe in some situations during pregnancy, not enough information is available to recommend SAM-e for pregnant women, except in specific circumstances.
If SAM-e Safe for Pregnant Women?
As mentioned, not enough information is available to determine if SAM-e is safe for use during pregnancy. The supplement has been studied for treating intrahepatic cholestasis of pregnancy (a decreased ability of the liver to secrete bile), but only in the third trimester and only in IV, not oral, form. These studies did not indicate that SAM-e is likely to cause problems in pregnant women. However, results of these studies should not be interpreted to mean that SAM-e is safe for all pregnant women (in any trimester) when taken in any form.
If you are pregnant, do not take SAM-e (or any prescription drug, non-prescription medication, or supplement) without your healthcare provider's approval. Just because something is "natural" or available without a prescription does not mean it is safe, especially during pregnancy.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Jellin JM, editor. Pharmacist's Letter/Prescriber's Letter Natural Medicines Comprehensive Database Web site. Available at: http://naturaldatabase.com/. Accessed February 29, 2008.
Agency for Healthcare Research and Quality (AHRQ). U.S. Department of Health and Human Services. S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease: Evidence report/technology assessment: Number 64 (August 2002). AHRQ Web site. Available at: http://www.ahrq.gov/clinic/epcsums/samesum.htm. Accessed February 29, 2008.
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