Mental Health Home > Prolixin Warnings and Precautions

Prolixin warnings and precautions to be aware of before starting treatment include potential drug interactions and the danger of developing a life-threatening condition called neuroleptic malignant syndrome. Women who are pregnant may not be prescribed the drug. Prolixin warnings and precautions also extend to those who are allergic to any of the ingredients used to make the drug or who have subcortical brain damage.

Prolixin: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Prolixin® (fluphenazine) if you have:
Also let your healthcare provider know if you:
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding
  • Have an upcoming surgery
  • Drink alcohol.
You should also be sure to tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Prolixin Warnings and Precautions

Warnings and precautions to be aware of prior to taking Prolixin include the following:
  • Prolixin can cause a life-threatening condition called neuroleptic malignant syndrome (NMS). Some symptoms of the condition include:
    • A high fever
    • Stiff muscles
    • Confusion
    • An irregular pulse or blood pressure
    • A fast heart rate (tachycardia)
    • Sweating
    • Irregular heart rhythms (arrhythmias).
Tell your healthcare provider right away if think you might have NMS.
  • Prolixin can cause tardive dyskinesia, a condition involving unusual, uncontrollable body or facial movements. The condition can become permanent even if Prolixin is stopped. The best way to prevent it from becoming permanent is to tell your healthcare provider right away if you notice any abnormal movements (including abnormal movements of the tongue) while taking the drug.
  • You may need to stop or reduce your dose of Prolixin before a surgery -- ask your healthcare provider.
  • Prolixin can impair your mental or physical abilities to drive a car or operate heavy machinery. Make sure you know how the medication affects you before you do any activities that require mental concentration or physical coordination.
  • Prolixin can increase the risk of liver damage or eye damage. Let your healthcare provider know if you have liver disease or if you develop any vision changes while taking the drug.
  • Prolixin can cause a drop in blood pressure (hypotension). This can cause a person to have lightheadedness or dizziness, or to faint. Tell your healthcare provider if you have any of these symptoms when standing. Hypotension can be especially dangerous in people with heart disease or congestive heart failure (CHF). Combining alcohol with Prolixin can also increase the risk of hypotension (see Alcohol and Prolixin).
  • The medication may increase the risk of seizures. Before starting Prolixin, tell your healthcare provider if you have epilepsy or a history of seizures.
  • Prolixin is considered a pregnancy Category C medication. This means that it may not be safe to take during pregnancy. Be sure to talk with your healthcare provider about the risks and benefits of using the drug while pregnant (see Prolixin and Pregnancy).
  • It is not known if Prolixin passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider before taking the drug (see Prolixin and Breastfeeding).
  • Prolixin can interact with certain other medications (see Prolixin Drug Interactions).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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