Perphenazine is used to treat symptoms of schizophrenia, as well as severe nausea and vomiting. It works by lessening or blocking the effects of a certain chemical in the brain. The medication comes in tablet form and is usually taken two to four times a day. Commonly reported side effects can include drowsiness, unusual body movements, and blurred vision.
What Is Perphenazine?
Perphenazine (Trilafon®) is a prescription medicine known as a "typical antipsychotic" that has been licensed to treat schizophrenia. It is also approved to treat severe nausea and vomiting.
Who Makes This Drug?
Perphenazine was originally manufactured by Schering-Plough Corporation. Although brand-name perphenazine is no longer being made, generic versions are still available and are made by several different companies.
Perphenazine belongs to a group of medications called typical (or first-generation) antipsychotic medications. In particular, it is part of a group of medications called phenothiazines. It is not entirely known how the drug works. However, it is known to block or lessen the effects of dopamine, a chemical in the brain that may be elevated in people with schizophrenia.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: Approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed May 18, 2007.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 7th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2005.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed May 18, 2007.
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