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Perphenazine is used to treat symptoms of schizophrenia, as well as severe nausea and vomiting. It works by lessening or blocking the effects of a certain chemical in the brain. The medication comes in tablet form and is usually taken two to four times a day. Commonly reported side effects can include drowsiness, unusual body movements, and blurred vision.

What Is Perphenazine?

Perphenazine (Trilafon®) is a prescription medicine known as a "typical antipsychotic" that has been licensed to treat schizophrenia. It is also approved to treat severe nausea and vomiting.

Who Makes This Drug?

Perphenazine was originally manufactured by Schering-Plough Corporation. Although brand-name perphenazine is no longer being made, generic versions are still available and are made by several different companies.
(Click What Is Perphenazine Used For? for more information, including possible off-label uses.)

How Does It Work?

Perphenazine belongs to a group of medications called typical (or first-generation) antipsychotic medications. In particular, it is part of a group of medications called phenothiazines. It is not entirely known how the drug works. However, it is known to block or lessen the effects of dopamine, a chemical in the brain that may be elevated in people with schizophrenia.
Perphenazine is not a cure for schizophrenia. It only helps to control symptoms (see Symptoms of Schizophrenia).
Since dopamine can activate the part of the brain that controls nausea and vomiting, perphenazine can treat severe nausea and vomiting by lessening the effects of dopamine in the brain.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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