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Effects of Paliperidone

In previous clinical studies of paliperidone for the treatment of schizophrenia, people taking paliperidone experienced improvements in their schizophrenia symptoms (including hallucinations and suspiciousness), compared to those not taking it. Longer studies also showed that paliperidone can help prevent hospitalization due to schizophrenia and can help keep symptoms from returning.

When and How Do I Take It?

Following are some general considerations for when and how to take paliperidone:
  • The medication comes in tablet form. It is usually taken by mouth once a day in the morning. It also comes in a long-acting injectable form that is given just once a month (after the first two doses, which are given one week apart). 
  • You can take it with or without food. If it bothers your stomach, try taking it with food.
  • Paliperidone tablets are specially designed to slowly release the medication over time. They should be swallowed whole with water (or other liquids) and should not be crushed, chewed, or broken.
  • It should be taken at the same time each day to maintain even levels of the drug in your blood.
  • For the medication to work properly, it must be taken as prescribed. It will not work if you stop taking it.

Dosage Information

The dose of paliperidone that your healthcare provider recommends will vary depending on a number of factors, including:
  • Other medical conditions you may have
  • How you respond to the medication 
  • Other medications you may be currently taking.
As with any medication, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
(Click Paliperidone Dosing for more information.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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