Mental Health Home > Norpramin

Norpramin is a prescription drug licensed for the treatment of depression. Although it is not entirely clear how the antidepressant works, it is believed that it allows certain chemicals in the brain (serotonin and norepinephrine) to stay in the brain longer. This medication comes in tablet form and is generally taken one to four times a day. Side effects may include drowsiness, constipation, and dizziness.

What Is Norpramin?

Norpramin® (desipramine hydrochloride) is a prescription medication that is used to treat depression (also known as major depression or clinical depression).
(Click Norpramin Uses for more information on what this drug is used for, including possible off-label uses.)

Who Makes It?

Norpramin is made by Sanofi-Aventis. Generic Norpramin is made by several manufacturers of generic medications.

How Does Norpramin Work?

Norpramin belongs to a class of medications called tricyclic antidepressants. It is not entirely clear how Norpramin works. However, it is known that the medicine affects several chemicals in the brain, including serotonin and norepinephrine. It is thought that perhaps the medicine allows these chemical to stay in the brain longer, which can help with depression symptoms.

When and How to Take It

Some considerations to keep in mind while taking Norpramin include:
  • Norpramin comes in tablet form. It is usually taken by mouth one to four times daily.
  • You can take it with or without food. If the medicine upsets your stomach, try taking it with food.
  • Norpramin should be taken at the same time(s) each day to maintain an even level of the medication in your blood.
  • For Norpramin to work properly, you have to take it as prescribed. The medicine will not work if you stop taking it.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
Other Articles in This eMedTV Presentation

Topics & Medications


Related Channels

eMedTV Links
Copyright © 2006-2020 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.