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- Been taking opioid medicines, either for a medical or nonmedical reason
- Been using illegal or street drugs
- Liver disease, such as cirrhosis, liver failure, or hepatitis
- Kidney disease, such as kidney failure (renal failure)
- Heart disease
- Any allergies, including to foods, dyes, or preservatives.
- Pregnant or thinking of becoming pregnant (see Narcan and Pregnancy)
- Breastfeeding (see Narcan and Breastfeeding).