Mental Health Home > Mirtazapine

Mirtazapine is a prescription drug used to treat depression. It is believed to help produce more norepinephrine and serotonin in the brain when they become unbalanced by limiting the effects of certain reuptake inhibitors. The medication comes in tablet form and as an orally disintegrating tablet. Possible side effects of mirtazapine include dizziness, drowsiness, and weight gain.

What Is Mirtazapine?

Mirtazapine (Remeron®) is a prescription medicine used for the treatment of depression (also known as major depression or clinical depression).
(Click What Is Mirtazapine Used For? for more information, including possible off-label uses for the drug.)

Who Makes It?

Mirtazapine is manufactured by Organon USA. It is sold under the brand name Remeron. Generic mirtazapine is made by several manufacturers.

How Does Mirtazapine Work?

It is not entirely clear how mirtazapine works, since no other medications work exactly like it. The drug blocks several different kinds of receptors, including serotonin, norepinephrine, histamine, alpha, and muscarinic receptors.
It is thought that the antidepressant effects of this drug are due to its actions on serotonin and norepinephrine. These are chemicals used to send messages in between nerves. However, if serotonin or norepinephrine levels become unbalanced, it can cause a variety of conditions, including depression. Mirtazapine's actions on other types of receptors may cause some of its side effects, such as drowsiness or low blood pressure.
Certain receptors decrease the levels of serotonin and norepinephrine released by the nerves. Mirtazapine blocks these inhibitory receptors, causing more to be released. This may help to relieve the symptoms of depression.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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