Mental Health Home > Mirtazapine Dosing

The mirtazapine dosing guidelines that your healthcare provider will follow depend on factors such as your age, existing medical conditions you may have, and other medications you may also be taking. The recommended starting dose when treating depression is 15 mg, taken once a day. Your healthcare provider may increase your mirtazapine dosing amount if symptoms of depression continue, or decrease the dose if you develop side effects.

An Introduction to Mirtazapine Dosing

The dose of mirtazapine (Remeron®) that your healthcare provider prescribes will vary, depending on a number of factors, including:
  • Your age
  • Other medical conditions you may have
  • Other medications you are currently taking.
As is always the case, do not adjust your mirtazapine dose unless your healthcare provider specifically instructs you to do so.

Mirtazapine Dosing for Depression

The recommended starting dose when treating depression is mirtazapine 15 mg, taken once daily at bedtime. Your healthcare provider may increase the dosage if symptoms continue, or decrease the dose if side effects occur. The maximum recommended dose of mirtazapine is 45 mg per day.
Elderly people and those with kidney or liver problems may have higher levels of mirtazapine in their blood, and lower mirtazapine doses are often recommended for these people.

General Mirtazapine Dosing Information

Considerations for people taking mirtazapine include the following:
  • It may take several weeks before the beneficial effects of mirtazapine are felt. Try not to be discouraged if the drug does not work right away for you.
  • For people who have trouble swallowing tablets, mirtazapine also comes in an orally disintegrating tablet form. These tablets will rapidly dissolve on your tongue, with no need to drink water.
  • Do not cut the orally disintegrating tablets. Also, to avoid crushing the delicate tablets, do not try to push them through the foil blister. Peel back the foil to remove them.
  • Mirtazapine should be taken at the same times each day to maintain an even level of the drug in your blood. Because the medication usually causes drowsiness, it is generally best to take it in the evening before bedtime.
  • For mirtazapine to work properly, you have to take it as prescribed. The drug will not work if you take it differently from how your healthcare provider recommends.
  • If you are unsure about anything related to mirtazapine or mirtazapine dosing, talk to your doctor, nurse, or pharmacist. Do not stop taking the drug without first discussing it with your healthcare provider.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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