Mental Health Home > Drug Interactions With Methamphetamine

Drug interactions with methamphetamine can involve medications such as guanethidine, insulin, and monoamine oxidase inhibitors (MAOIs). Methamphetamine may also interact with tricyclic antidepressants and phenothiazine medications. Effects of these potential drug interactions involving methamphetamine can include such things as a reduction in the effectiveness of one or both drugs, an increased risk for low blood sugar, or an extreme increase in blood pressure.

Drug Interactions With Methamphetamine: An Overview

Methamphetamine hydrochloride (Desoxyn®) can potentially interact with several medicines. Some of the medicines that may lead to methamphetamine interactions include:
  • Guanethidine
  • Insulin
  • Monoamine oxidase inhibitors (MAOIs), including:



  • Phenothiazine medications, including:





Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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