Mental Health Home > Methadone Drug Interactions

There are a number of drugs that may interact with methadone. Problems can occur if the narcotic is taken with medicines such as antidepressants, sleep medications, or protease inhibitors. Some of these reactions could increase your risk of side effects (such as drowsiness, confusion, or difficulty breathing), decrease the effectiveness of the medications, or lead to more dangerous problems.

Methadone Interactions: An Overview

Methadone hydrochloride (Diskets®, Dolophine®, Methadose®) can potentially interact with a number of other medications. Some of the medicines that may lead to drug interactions with methadone include (but are not limited to):
  • CYP 3A4 inducer medications, such as:
  • CYP 3A4 inhibitor medications, such as:
  • Monoamine oxidase inhibitors (MAOIs), such as:
  • Some protease inhibitors, such as:
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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