Mental Health Home > Marplan Drug Interactions

In the case of Marplan, drug interactions may occur with medications such as barbiturates, blood pressure medications, and cold medications. Some of these drug interactions with Marplan can cause dangerous side effects, such as seizures or dangerously high blood pressure. Because there are numerous other drug interactions with Marplan (many of which are serious), be sure to talk to your healthcare provider before taking Marplan with any other prescribed medication or over-the-counter drugs.

Marplan Drug Interactions: An Introduction

Marplan® (isocarboxazid) can potentially interact with many medicines. Because there are so many Marplan drug interactions that can be very dangerous, it is important to check with your healthcare provider before taking any medication, whether prescription or over-the-counter. Make sure to tell all your healthcare providers (including dentists and surgeons) that you are taking Marplan.
Some of the medicines that may lead to Marplan interactions include:


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®





  • Other monoamine oxidase inhibitors (MAOIs), including:




    • Dopamine
    • Ephedrine
    • Epinephrine (Adrenalin®, EpiPen®)
    • Isometheptene (Duradrin®, Midrin®, Migquin®, Migratine®, Migrazone®, Migrin-A®)
    • Levonordefrin (Carbocaine® with Neo-Cobefrin®)
    • Midodrine (Orvaten™, ProAmatine®)
    • Norepinephrine (Levophed®


  • Stimulants, such as:





Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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