Mental Health Home > Marplan Alternatives

If Marplan is not working for you or if you are developing bothersome side effects, there are some alternatives you can try. Some Marplan alternatives may include things such as psychotherapy, other antidepressant medications, electroconvulsive therapy, and alternative (natural) therapies. Examples of medications that may be used as alternatives to Marplan include SSRIs, SNRIs, MAOIs, and tricyclic medications.

Marplan Alternatives: An Overview

Marplan® (isocarboxazid) is a prescription medicine used for the treatment of depression (also known as major depression or clinical depression). Marplan is part of a group of antidepressant medications called monoamine oxidase inhibitors.
Because of the potentially lethal drug and food interactions that may occur, MAOIs are usually used as a last resort, when other options have failed. Before deciding to take Marplan, you may want to make sure that you have tried several different options to treat your depression. Some of these Marplan alternatives include:
  • Therapy
  • Other depression medications (also known as antidepressants)
  • Electroconvulsive therapy
  • Alternative (natural) therapies.

Therapy as a Marplan Alternative

Many forms of psychotherapy, including some short-term therapies (10 to 20 weeks), can help people with depression. "Talk" therapies help patients gain insight into and resolve their problems through verbal exchange with the therapist, sometimes combined with "homework" assignments between sessions.
Behavioral therapists help patients learn how to obtain more satisfaction through their own actions and how to unlearn the behavioral patterns that contribute to or result from their depression.
(Click Psychotherapy for Depression to learn more about this depression treatment option.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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