Mental Health Home > Maprotiline and Suicide
It is possible to develop side effects or complications while taking an antidepressant like maprotiline. Suicide risk, for example, is slightly increased in children and teens taking antidepressants. It is important to talk to a healthcare provider if you (or your child) develop any signs of suicidal behavior, such as agitation, violent behavior, or thoughts about death.
Maprotiline hydrochloride (Ludiomil®) is a prescription medication used for the treatment of depression in adults. It is part of a group of medications called tricyclic antidepressants. As with all antidepressants, there may be an increased risk of suicidal behavior when taking maprotiline.
The U.S. Food and Drug Administration (FDA) has issued a special warning about the risk of suicidal thinking and behavior with antidepressant use in children and teenagers. The warning was issued due to concerns that antidepressants seemed to increase the risk of suicidal behavior in children and teenagers in clinical studies.
Although maprotiline is not approved for use in children and teenagers, it may be used "off-label" for this use.
In clinical studies, it did appear that there was a slightly increased risk of suicidal behavior in children and teenagers who took antidepressants, including maprotiline. In one study, about 4 percent of children and teens taking an antidepressant had suicidal thoughts or behavior, compared to 2 percent of children and teens who were not taking an antidepressant. This study looked at all suicidal behavior, including suicides, attempted suicides, and thoughts about committing suicide. It is important to note that no one in the study actually committed suicide.
It is difficult to know for sure if antidepressants cause suicidal behavior. To make matters more confusing, depression itself can cause suicidal behavior. The bottom line: you should report any signs of suicidal behavior to your healthcare professional, whether you are taking an antidepressant or not.
Certain people seem to be at higher risk for suicidal behavior while taking antidepressants. This includes people with bipolar disorder (or a family history of bipolar disorder) and people who have attempted suicide (or have a family history of suicide attempts).