Mental Health Home > Does L-Methylfolate Work?

People who have a folate deficiency, depression, or peripheral neuropathy may benefit from L-methylfolate. But does this vitamin work? Research on L-methylfolate has suggested that this active form of folic acid may be an effective component in the treatment of these and other conditions. However, more research is necessary to determine the validity of these uses.

Does L-Methylfolate Really Work?

L-methylfolate is claimed to work for a few different conditions, although some potential benefits are supported by more scientific research than others. This article will address the effectiveness of L-methylfolate for a few different uses, including:
 
  • Pregnancy
  • Hyperhomocysteinemia
  • Folate deficiency
  • Peripheral neuropathy
  • Depression.
 
L-Methylfolate Use During Pregnancy
The need for adequate folate consumption increases during pregnancy. Numerous studies support the use of folic acid supplementation to prevent folate deficiency and anemia in pregnant women. Low folate levels have been linked to miscarriages and neural tube defects, such as spina bifida. Adequate folic acid intake before and during early pregnancy reduces the risk for these complications.
 
L-methylfolate can be used in place of folic acid during pregnancy. It is an active ingredient in several prenatal vitamins. Some of the prenatal vitamins that contain L-methylfolate include:
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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