Mental Health Home > Glutamine Drug Interactions

When chemotherapy medications, lactulose, or seizure medications are taken together with glutamine, drug interactions could potentially occur. Glutamine supplementation may interfere with the effectiveness of these medicines and increase your risk of side effects. To help prevent potentially dangerous drug interactions with glutamine, make sure to tell your healthcare provider about all other medicines you are currently taking.

An Introduction to Glutamine Drug Interactions

Even though glutamine (also known as L-glutamine) is a natural product, it can potentially interact with some medicines. Some of these medicines that may lead to glutamine drug interactions include:
 
  • Chemotherapy
  • Lactulose (Constulose®, Enulose®, Generlac®, Kristalose®)
  • Seizure medications.
     

Glutamine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when glutamine supplements are combined with any of the drugs listed above.
 
Chemotherapy
There is some concern that glutamine may stimulate tumor growth or could affect the way the body handles chemotherapy medications, although these problems have not been confirmed by studies. If you are undergoing chemotherapy, check with your healthcare provider before taking a glutamine supplement.
 
Lactulose (Constulose, Enulose, Generlac, Kristalose)
Although lactulose is most often used as a laxative, it is sometimes used to treat or prevent high ammonia levels due to liver disease. Since the body can break glutamine down into ammonia, it is possible that glutamine supplementation may interfere with the effectiveness of lactulose for treating or preventing high ammonia.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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