Mental Health Home > Drug Interactions With Dexmethylphenidate Extended-Release

Taking dexmethylphenidate extended-release with certain other medications -- such as antacids, seizure medications, and some antidepressants -- can cause problems. Drug interactions with dexmethylphenidate extended-release can increase your risk of serious side effects or change the amounts of some drugs in your blood, among other things. It is important to talk with your healthcare provider about any dexmethylphenidate extended-release drug interactions that may apply to you.

Drug Interactions With Dexmethylphenidate Extended-Release: An Overview

Dexmethylphenidate extended-release (Focalin XR®) can potentially interact with a number of other drugs. Some of the drugs that may lead to dexmethylphenidate extended-release interactions include:
  • Antacids or acid suppressants, such as:



  • Monoamine oxidase inhibitors (MAOIs), including:




    • Dopamine (Intropin®)
    • Dobutamine (Dobutrex®)
    • Epinephrine (Adrenalin®, EpiPen®)
    • Norepinephrine (Levophed®)






Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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