Mental Health Home > Desvenlafaxine Dosage

For most people, the recommended desvenlafaxine dosage for treating depression is 50 mg a day. If your symptoms do not improve and you tolerate the medication well, your healthcare provider may choose to increase your dose. According to desvenlafaxine dosing guidelines, people with liver disease should not take more than 100 mg per day.

Desvenlafaxine Dosage: An Introduction

The dose of desvenlafaxine succinate (Pristiq®) that your healthcare provider prescribes will vary, depending on a number of factors, including:
  • How you respond to desvenlafaxine
  • Other medical conditions you may have
  • Other medications you may be taking.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Desvenlafaxine Dosage for Depression

The recommended dose of desvenlafaxine for depression treatment is 50 mg per day. In studies, higher doses (up to 400 mg per day) were used successfully; however, doses higher than 50 mg were no more effective and caused more side effects, compared to a dose of 50 mg per day.
Your healthcare provider may decide to increase your desvenlafaxine dosage if you tolerate it well but have not achieved a satisfactory response to the medication. However, people with liver disease (such as liver failure, hepatitis, or cirrhosis) should not take more than 100 mg per day.
As with most antidepressants, in general, desvenlafaxine should not be stopped abruptly, as this could cause withdrawal symptoms. Your healthcare provider will instruct you on exactly how to stop taking the drug. Since the tablets cannot be split in half to achieve a lower dose, the only way to decrease the dose slowly is to take desvenlafaxine less often, such as every other day or every third day.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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