Mental Health Home > Drug Interactions With Buspirone
The following sections explain in detail the potentially negative interactions that can occur when buspirone is combined with any of the drugs listed above.
Combining alcohol with buspirone can increase your risk of side effects, such as drowsiness or dizziness. It is best to avoid alcohol while taking buspirone (see BuSpar and Alcohol).
Certain Antibiotics or Antifungals
Some antibiotic or antifungal medications can increase the level of buspirone in your blood, possibly increasing your risk of side effects of buspirone. Talk to your healthcare provider before taking an antibiotic or antifungal with buspirone.
Certain Seizure Medications
Some seizure medications can decrease the level of buspirone in your blood, perhaps making it less effective. Talk to your healthcare provider before taking these medications together.
Diltiazem can increase the level of buspirone in your blood, possibly increasing your risk of side effects. Talk to your healthcare provider before using the medications together.
Monoamine Oxidase Inhibitors
Taking an MAOI with buspirone can cause serious side effects, such as dangerously high blood pressure (hypertension). In general, these medications should not be taken together.
Combining buspirone with nefazodone can increase the level of both medications in your blood, which may increase your risk of side effects, especially lightheadedness, weakness, dizziness, and drowsiness. Your healthcare provider may need to adjust your dose of these medications to prevent drug interactions from occurring.