Mental Health Home > Bupropion Hydrobromide

What If I Take an Overdose?

An overdose with bupropion hydrobromide can cause life-threatening complications. If you happen to take too much of this medication, seek immediate medical attention.
(Click Aplenzin Overdose for more information.)

What Should I Do If I Miss a Dose of Bupropion Hydrobromide?

If you do not take your bupropion hydrobromide as scheduled, take your missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose of this antidepressant.
Because bupropion hydrobromide should be taken in the morning, you may want to consider skipping a missed dose rather than taking it later during the day (as this might cause insomnia).

How Does It Work?

Bupropion hydrobromide is a norepinephrine and dopamine reuptake inhibitor, or NDRI for short. NDRIs, such as bupropion hydrobromide, affect specific chemicals within the brain known as norepinephrine and dopamine. Norepinephrine and dopamine are two of several chemicals used to send messages from one nerve cell to another.
As a message travels down a nerve, it causes the end of the cell to release a neurotransmitter chemical such as norepinephrine or dopamine. The neurotransmitter enters the gap between the first nerve cell and the one next to it. When enough of the neurotransmitter reaches the second nerve cell, it activates receptors on the cell and the message continues on its way. The first cell then quickly absorbs any excess neurotransmitter that remains in the gap between cells; this is called "reuptake."
Normally, this process works without any problems. But when the levels of dopamine and norepinephrine become unbalanced, it can cause a variety of conditions, including depression. Bupropion hydrobromide helps to block the reuptake of norepinephrine and dopamine so more remains in the space between the brain's nerve cells. This gives the chemicals a better chance of activating the receptors on the next nerve cell.
Currently, the only NDRI antidepressants approved for use are medications containing bupropion. Bupropion hydrobromide is a once-daily, long-acting version of bupropion. Bupropion also comes in several other forms. For more information on the other forms of bupropion, see:
Bupropion hydrobromide contains bupropion hydrobromide; all the other bupropion products contain bupropion hydrochloride. This difference is unlikely to be significant in any meaningful way, at least in terms of effectiveness. Very preliminary evidence in mice suggests that bupropion hydrobromide might be less likely than bupropion hydrochloride to cause seizures.
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Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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