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Buproban is a drug approved for smoking cessation. The prescription medicine works by blocking the reuptake of certain chemicals in the brain. Buproban may be used along with smoking cessation counseling. Also, in one previous study, Buproban was more effective at helping people to stop smoking when combined with nicotine patches. Buproban is typically taken twice a day as a tablet. A few side effects of Buproban include insomnia, dry mouth, and dizziness.

What Is Buproban?

Buproban® (bupropion SR) is a prescription medicine used to help people stop smoking. It is a generic version of Zyban®.
(Click What Is Buproban Used For? for more information on what the drug is used for, including possible off-label uses.)

Who Makes Buproban?

Buproban is manufactured by Teva Pharmaceuticals.

How Does Buproban Work?

Buproban was first developed as an antidepressant. In fact, bupropion (the active ingredient in Buproban) is available in several products approved for the treatment of depression (Aplenzin™, Budeprion SR®, Budeprion XL®, Forfivo™ XL, Wellbutrin®, Wellbutrin SR®, and Wellbutrin XL®).
Buproban is part of a class of drugs known as norepinephrine and dopamine reuptake inhibitors (or NDRIs for short). NDRIs, such as Buproban, act on specific chemicals within the brain known as norepinephrine and dopamine. These are two of several chemicals used to send messages from one nerve cell to another.
As a message travels down a nerve, it causes the end of the cell to release norepinephrine (or dopamine). The norepinephrine (or dopamine) enters the gap between the first nerve cell and the one next to it. When enough norepinephrine or dopamine reaches the second nerve cell, it activates receptors on the cell, and the message continues on its way. The first cell then quickly absorbs any norepinephrine or dopamine that remains in the gap between cells. This is called "reuptake."
Buproban helps to block the reuptake of norepinephrine and dopamine so that more of each chemical remains in the space between the brain's nerve cells. This gives these substances a better chance of activating the receptors on the next nerve cell. It is thought that this action helps people to be more successful at quitting smoking.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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