Mental Health Home > Side Effects of Amoxapine

Among the possible side effects of amoxapine, dry mouth, constipation, and drowsiness are the most common. Less common side effects (occurring in less than 1 percent of patients) include vomiting, impotence, and hair loss. Although amoxapine side effects are minor most of the time, some problems may require immediate medical attention. These more serious side effects include changes in heart rhythm, extremely high fever, and seizures.

Side Effects of Amoxapine: An Introduction

As with any medicine, there are possible side effects with amoxapine (Asendin®). However, not everyone who takes the antidepressant will experience side effects. In fact, most people tolerate the drug well. When side effects do occur, in many cases they are minor, meaning they either require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, possible side effects with amoxapine. Your healthcare provider can discuss a more complete list of amoxapine side effects with you.)

Common Side Effects With Amoxapine

Amoxapine has been studied thoroughly in clinical trials in which the side effects seen in a group of people taking the drug are documented and compared to another group not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
In these studies, the most common side effects of amoxapine included:
  • Drowsiness -- in up to 14 percent of people
  • Dry mouth -- up to 14 percent (see Amoxapine and Dry Mouth)
  • Constipation -- up to 12 percent
  • Blurred vision -- up to 7 percent.
Other common side effects (occurring 1 percent to 6 percent of people) included:
  • Anxiety, restlessness, or nervousness
  • Insomnia
  • Shakiness (tremor)
  • Confusion
  • Excitement
  • Nightmares
  • Problems with muscle coordination
  • Water retention
  • Increased levels of prolactin (a hormone) in the blood
  • Nausea
  • Headache
  • Fatigue or weakness
  • Increased appetite
  • Increased sweating.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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