Mental Health Home > Drug Interactions With Alprazolam

Among the medications that may potentially cause drug interactions with alprazolam are protease inhibitors, barbiturates, and certain antibiotics or antifungals. Alprazolam drug interactions can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. To reduce your chances of developing alprazolam interactions, be sure to talk with your pharmacist or healthcare provider about any interactions that may apply to you.

An Overview of Alprazolam Drug Interactions

Alprazolam (Xanax®) can potentially interact with several other medications. Some of these medicines that may lead to alprazolam interactions include:



  • Barbiturates, including:


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)


  • Certain antibiotics or antifungals, including:





  • Protease inhibitors, such as:



  • Seizure medications
  • Sleep medications.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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