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Drug Interactions With Lurasidone

Drug Interactions With Lurasidone Explained

The following sections explain in detail the potentially negative interactions that can occur when lurasidone is combined with any of the drugs listed above.
 
CYP 3A4 Inducers
Lurasidone is metabolized by a specific liver enzyme known as CYP 3A4. Medications known as CYP 3A4 inducers speed up the activity of this enzyme, causing a decrease in the level of lurasidone in the blood. This could cause lurasidone to be less effective.
 
Different drugs induce CYP 3A4 to different extents. Drugs that strongly induce CYP 3A4 should not be combined with lurasidone, while those that moderately or weakly induce CYP 3A4 can be combined with lurasidone with caution. Because many drugs induce CYP 3A4 to various extents, check with your healthcare provider before combining lurasidone with any medication.
 
CYP 3A4 Inhibitors
Lurasidone is metabolized by a specific liver enzyme known as CYP 3A4. Medications known as CYP 3A4 inhibitors slow down the activity of this enzyme, causing an increase in the level of lurasidone in the blood. This could lead to serious side effects of lurasidone.
 
Different drugs inhibit CYP 3A4 to different extents. Drugs that strongly inhibit CYP 3A4 should not be combined with lurasidone, while those that moderately inhibit CYP 3A4 can be combined with a lurasidone dosage of no more than 80 mg per day. When used with moderate CYP 3A4 inhibitors, the recommended lurasidone starting dose is 20 mg per day.
 
Because many drugs inhibit CYP 3A4 to various extents, check with your healthcare provider before combining lurasidone with any medication.
 

Final Thoughts

It is possible that not all lurasidone drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
 
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