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Precautions and Warnings With Loxapine

Precautions and warnings with loxapine should be reviewed before starting treatment. For example, the drug can increase your risk of liver damage, increase the level of prolactin in your blood, and cause a drop in blood pressure. Precautions and warnings with loxapine also extend to those who are in a decreased state of consciousness or who are allergic to any ingredients used to make the drug.

Loxapine: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking loxapine (Loxitane®) if you have:
 
Also, let your healthcare provider know if you:
 
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding
  • Drink alcohol.
     
You should also be sure to tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 

Specific Precautions and Warnings With Loxapine

Warnings and precautions to be aware of prior to taking loxapine include the following:
 
  • Loxapine can cause tardive dyskinesia. This is a condition involving unusual, uncontrollable body or facial movements. The condition can become permanent even if loxapine is stopped. The best way to prevent this is to tell your healthcare provider right away if you notice any abnormal movements (including abnormal movements of the tongue) while taking the drug.
     
  • The medication can cause a life-threatening condition called neuroleptic malignant syndrome (NMS). Some symptoms of NMS include:
o A high fever
o Stiff muscles
o Confusion
o Irregular pulse or blood pressure
o A fast heart rate (tachycardia)
o Sweating
o Irregular heart rhythms (arrhythmias).
Tell your healthcare provider right away if you think you might have NMS.
  • Loxapine can impair your mental or physical abilities to drive a car or operate heavy machinery. Make sure you know how the drug affects you before you do any activities that require mental concentration or physical coordination.
     
  • Loxapine can increase the risk of liver damage or eye damage. Be sure to let your healthcare provider know if you have signs of liver damage (such as yellow eyes or skin) or any vision changes during treatment.
     
  • The medication can increase the level of prolactin (a natural hormone) in your blood. This can cause various problems, such as breast enlargement, breast discharge, menstrual changes, or sexual problems.
     
  • Loxapine can cause a drop in blood pressure (hypotension). This can cause a person to have lightheadedness or dizziness or to faint. Tell your healthcare provider if you have any of these symptoms when standing. Hypotension can be especially dangerous in people with heart disease or congestive heart failure (CHF). Combining alcohol with loxapine can also increase the risk of hypotension (see Alcohol and Loxitane).
     
  • The medication may increase the risk of seizures. Before starting loxapine, tell your healthcare provider if you have epilepsy or a history of seizures.
     
  • Loxapine is considered a pregnancy Category C medication. This means that it may not be safe to take while pregnant. Be sure to talk with your healthcare provider about the risks and benefits of using the drug during pregnancy (see Loxitane and Pregnancy).
     
  • It is not known if loxapine passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider before taking the drug (see Loxitane and Breastfeeding).
     
  • Loxapine can interact with certain other medications (see Drug Interactions With Loxapine).
 
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Information on Loxapine

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