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Drug Interactions With Lisdexamfetamine

Lisdexamfetamine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when lisdexamfetamine is combined with any of the drugs listed above.
 
Acetazolamide (Diamox)
Taking lisdexamfetamine and acetazolamide together can increase the amount of lisdexamfetamine in the blood, increasing your risk of side effects. Your healthcare provider may need to decrease your lisdexamfetamine dosage.
 
Ammonium Chloride
Taking lisdexamfetamine and ammonium chloride together can decrease the amount of lisdexamfetamine in the blood, perhaps making lisdexamfetamine less effective. Your healthcare provider may need to increase your dose of lisdexamfetamine.
 
Certain Antacids
Taking lisdexamfetamine with very high doses of certain antacids (such as calcium carbonate) can increase the amount of lisdexamfetamine in the blood, resulting in possible side effects. This is probably not a problem with occasional use of antacids. Your healthcare provider may need to adjust your dose of these medications.
 
Certain Sleep Medications
Taking lisdexamfetamine with certain sleep medications, such as diphenhydramine, can decrease the effectiveness of the sleep medication. Your healthcare provider may need to adjust your dose of these medications.
 
Chlorpromazine (Thorazine)
Taking lisdexamfetamine and chlorpromazine together can change the way the brain reacts to lisdexamfetamine, making lisdexamfetamine less effective. Your healthcare provider may need to adjust your dose of these medications.
 
Ethosuximide (Zarontin)
Taking lisdexamfetamine and ethosuximide together can cause ethosuximide to be absorbed in the body more slowly, perhaps making it less effective. Your healthcare provider may need to adjust your dose of these drugs.
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