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Clinical Effects

Levomilnacipran has been studied in three clinical studies that included people with major depressive disorder between the ages of 18 and 78 years old. In these studies, people were randomly assigned to receive either levomilnacipran or a placebo (a "sugar pill" with no active ingredients). In all three studies, people taking levomilnacipran had a greater improvement in their depressive symptoms after eight weeks of treatment compared to those taking the placebo.

When and How to Take This Medicine

Some general considerations to keep in mind during treatment with levomilnacipran include the following:
  • Levomilnacipran comes in the form of a capsule. It is usually taken by mouth once a day.
  • You can take your dose with or without food. Try taking it with food if it upsets your stomach.
  • This medication can be taken any time during the day. If it makes you drowsy, try taking it at night. If it causes insomnia, take it in the morning.
  • You should take your dose at the same time each day to keep an even level of the drug in your bloodstream.
  • Levomilnacipran should be swallowed whole. Do not cut, crush, or chew the capsules.
  • Suddenly stopping medications like levomilnacipran can cause uncomfortable withdrawal-type symptoms (see Fetzima Withdrawal). If you need to stop taking this medication, your healthcare provider will likely slowly reduce your dose.
  • For the medication to work properly, it must be taken as prescribed. Levomilnacipran will not work if you stop taking it.  

Dosing Information for Levomilnacipran

The dose of levomilnacipran your healthcare provider recommends will vary, depending on a number of factors, including:
  • How you respond to levomilnacipran
  • Other medications you are taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
(Click Levomilnacipran Dosage for more information.)
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Levomilnacipran Drug Information

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