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Levomilnacipran

Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to taking this medication if you have:
 
  • Kidney disease, such as kidney failure (renal failure)
  • Glaucoma
  • High blood pressure (hypertension)
  • A fast heart rate
  • Heart problems
  • Ever had a seizure
  • Bipolar disorder or a family member with bipolar disorder
  • Ever had an abnormally high mood (mania)
  • Had thoughts of suicide or of harming yourself
  • Problems urinating
  • An enlarged prostate
  • Been told you have low blood sodium levels (hyponatremia)
  • Ever had bleeding problems
  • Any allergies, including to foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you:
   
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 
(Click Precautions and Warnings With Levomilnacipran to learn more, including information on who should not take the drug.)
 

How Does Levomilnacipran Work?

Levomilnacipran belongs to a class of medicines called serotonin-norepinephrine reuptake inhibitors (SNRIs). SNRIs work by increasing levels of the brain chemicals serotonin and norepinephrine. These are neurotransmitters -- chemical messengers used by nerve cells to send messages to one another. An imbalance of these brain chemicals is thought to be at least partially related to the symptoms of depression.
 
Neurons, or nerve cells, have tiny spaces between them. Transmitting neurons release chemicals such as serotonin or norepinephrine into that space as a way of sending a message to a receiving neuron. After the receiving neuron receives the message, the transmitting neuron can absorb the chemical to use it again later. This is called reuptake.
 
Levomilnacipran works by blocking the reuptake of serotonin and norepinephrine. By blocking the transmitting neuron from absorbing serotonin and norepinephrine, levomilnacipran increases the amount available in the space between the nerve cells.
 
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Levomilnacipran Drug Information

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