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Levomilnacipran Mechanism of Action

Levomilnacipran (Fetzima™) is a medication approved for the treatment of major depressive disorder, also known as major depression or clinical depression. It is available by prescription only and comes as a capsule that is taken once daily.
 
So how does levomilnacipran work? It is part of a class of drugs called serotonin-norepinephrine reuptake inhibitors (SNRIs). Levomilnacipran's mechanism of action involves increasing the levels of certain brain chemicals called serotonin and norepinephrine. These chemicals are used to send messages from one nerve cell to another. An imbalance in the levels of these chemicals is believed to be partially responsible for many symptoms of depression.
 
Nerve cells (called neurons) have tiny spaces between them. Transmitting neurons release chemicals such as serotonin or norepinephrine into that space as a way of sending a message to a receiving neuron. After the receiving neuron receives the message, the transmitting neuron can absorb the chemical to use it again later (known as "reuptake").
 
Levomilnacipran works by blocking the reuptake of serotonin and norepinephrine, increasing the amount available in the space between the nerve cells.
 
(Click Levomilnacipran for more information on the mechanism of action for this drug, including how it works, clinical research that has been done, and possible side effects.)
 
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